Biomedical Informatics Research Laboratory (BIRL) at LUMS aims to develop next generation modelling and simulation software for applications in proteomics and Systems Biology. Currently, the lab is developing a next-generation multiscale cancer modelling and simulation pipeline for integrative investigations into tumorigenesis. The group is also developing a high performance top-down proteomics search engine for protein identification from high resolution mass spectrometry data. The lab is also involved in BIGDATA mining for mobile health applications and associated clinical informatics.