Catalysis and Green Chemistry Group| LUMS

The research interests of our group are at the interface of organometallic chemistry and organic synthetic methodology. The main focus area of our research is the development of novel green synthetic methodologies, utilizing transition metal catalysis, for the functionalization of aromatic hydrocarbons. Our newly developed catalytic reactions provide rapid access to previously inaccessible materials which can have potential applications in wide range of areas including medicinal chemistry, agrochemicals, organic electronic materials, and photoredox catalysis etc.

Currently active research projects include:

Design & Synthesis of New Bioactive compounds (Anti-Fungal, Anti-Biotic, as well as Agrochemicals).
Asymmetric Synthesis
Visible Light Photo Catalysis
Development of New Green Synthetic Methodologies
Remediation of Contaminated Water

Present Group Members

Name
Fatima Hameed	BS, LUMS 2017	Senior Year Project
Mahwish Kanwal	MS, LUMS 2017	MS Research Project
Tayyaba Shahzadi	PhD, LUMS, 2018	PhD Research Projects
Soneela Asghar	PhD, LUMS, 2018	Currently Visiting University of Bristol UK on Commonwealth Scholarship for one year
Fahad Khan	PhD, Hazara University	Visiting PhD Student

Past Group Members

Name			Current Position
Zain Yousaf	BS, LUMS, 2012	BS Senior Year Project	Research Chemist at AMRI, USA
Waqas Rasheed	BS LUMS, 2013	Summer Internship	PhD student at University of Minnesota, USA
Ahmad Yousaf	BS LUMS, 2014	BS Senior Year Project	PhD student at Arizona State University, USA
Wardha Ejaz	BS LUMS, 2014	Summer Internship	PhD student at University of Massachusetts Amherst, USA
Hassan Haved	BS LUMS, 2015	BS Senior Year Project	PhD student at Rice University, USA
M. Ahmad Awais	BS LUMS, 2016	BS Senior Year Project	PhD student at University of Chicago, USA
Saba Kanwal	MS, LUMS, 2016	MS Research Project	Lab Instructor LUMS
Auj-e-Sana		Lab Instructor LUMS
Noor ul Ann		Lab Instructor LUMS	Lecturer in Punjab Edu Department
Shehla Malik		Lab Instructor LUMS	Assistant Prof. Govt. College for Women University Bahawalpur

Ghayoor Abbas Chotana

RESEARCH PUBLICATIONS

Ikram, H.M.; Rasool, N.; Zubair, M.; Khan, K. M.; Chotana, Ghayoor A.; Akhtar, M. N.; Abu, N.; Alitheen, N.B.; Elgorban, A.M.; Rana, U.A. “Efficient Double Suzuki Cross-Coupling Reactions of 2,5-Dibromo-3-hexylthiophene: Anti-Tumor, Haemolytic, Anti-Thrombolytic and Biofilm Inhibition Studies” Molecules 2016, 21(8), 977-987.

Tariq, S. R.; Shafiq, M.; & Chotana, Ghayoor A. “Distribution of heavy metals in the soils associated with the commonly used pesticides in cotton fields” Scientifica, 2016.

Batool, F.; Parveen, S.; Emwas, A.-H.; Sioud, S.; Gao, X.; Munawar, M. A.; Chotana, Ghayoor A.* “Synthesis of Fluoroalkoxy Substituted Arylboronic Esters by Iridium-Catalyzed Aromatic C–H Borylation” Org. Lett., 2015, 17 (17), pp 4256–4259.

Ghaffari, B.; Vanchura, B. A.; Chotana, Ghayoor A.; Staples, R. J.; Holmes, D.; Maleczka, R. E., Jr.; Smith, M. R., III. “Reversible Borylene Formation from Ring Opening of Pinacolborane and Other Intermediates Generated from Five-Coordinate Tris-Boryl Complexes: Implications for Catalytic C–H Borylation” Organometallics, 2015, 34 (19), pp 4732–4740.

Kallepalli, V. A.; Gore, K. A.; Shi, F.; Sanchez, L.; Chotana, Ghayoor A.; Miller, S. L.; Maleczka, R. E., Jr.; Smith, M. R., III. “Harnessing C–H Borylation/Deborylation for Selective Deuteration, Synthesis of Boronate Esters, and Late Stage Functionalization” J. Org. Chem. 2015, 80, 8341-8353.

Ikram, H.M.; Rasool, N.; Ahmad, G.; Chotana, Ghayoor A.; Musharraf, S.G.; Zubair, M.; Rana, U.A.; Zia-Ul-Haq, M.; Jaafar, H.Z. “Selective C-Arylation of 2,5-Dibromo-3-hexylthiophene via Suzuki Cross Coupling Reaction and Their Pharmacological Aspects” Molecules 2015, 20, 5202-5214.

Chotana, Ghayoor A.; Vanchura, B. A. II; Tse, Man-Kin; Staples, R. J.; Maleczka, R. E., Jr.; Smith, M. R., III. “Getting the Sterics Just Right: A Five Coordinate Iridium Trisboryl Complex that Reacts with C–H Bonds at Room Temperature” Chem. Commun. 2009, 38, 5731-5733.

Chotana, Ghayoor A.; Kallepalli, V. A.; Maleczka, R. E., Jr.; Smith, M. R., III. “Iridium–catalyzed Borylation of Thiophenes: Versatile, Synthetic Elaboration Founded on Selective C–H Functionalization” Tetrahedron 2008, 64 (26), 6103-6114. Invited paper in the special issue of Tetrahedron on Catalytic Aromatic C–H Activation.

Paul, S.; Chotana, Ghayoor A.; Holmes, D,; Reichle, R. C.; Maleczka, R. E., Jr.; Smith M, R., III. “Ir Catalyzed Functionalization of 2-Substituted Indoles at the 7-Position: Nitrogen Directed Aromatic Borylation” J. Am. Chem. Soc. 2006, 128 (49), 15552-15553.

Holmes, D.; Chotana, Ghayoor A.; Maleczka, R. E., Jr.; Smith, M. R., III. “One-Pot Borylation/Amination Reactions: Synthesis of Arylamine Boronate Esters from Halogenated Arenes” Org. Lett. 2006, 8 (7), 1407–1410.

Chotana, Ghayoor A.; Rak, M. A.; Smith, M. R., III. “Sterically directed Functionalization of Aromatic C-H bonds: Selective Borylation ortho to Cyano Groups in Arenes and Heterocycles” J. Am. Chem. Soc. 2005, 127 (30), 10539-10544.

Ikram, M.; Rauf, M.; Chotana, Ghayoor A.; Bukhari, N. “Levels of Lead in Solvent & Water Based Paints Manufactured in Pakistan” Sci. Int. (Lahore, Pakistan), 2000, 12 (3), 255-256.

Ikram, M.; Rauf, M. A.; Tahir, S. S.; Chotana, Ghayoor A. “Levels of Selected Toxic Metals in Solvent Based Paints Manufactured in Pakistan” Int. J. Environ. Studies, 1999, 56 (3), 234-235.

PATENTS & PATENT APPLICATIONS:

Smith, M. R., III.; Maleczka, R. E., Jr.; Chotana, Ghayoor A. Process for Producing Cyano Substituted Arenes Boranes and Compounds. U.S. Appl. Publ. 20060281939, 2006, and U.S. Pat. # 7,514,563.

Smith, M. R., III.; Maleczka, R. E., Jr.; Chotana, Ghayoor A.; Kallepalli, V. A.; Paul, S. Process for the Preparation of Borylated Thiophenes. U.S. Pat. Appl. Publ. 20080091035, 2008.

Smith, M. R., III.; Maleczka, R. E., Jr.; Chotana, Ghayoor A.; Paul, S. Process for the Preparation of 2-Substituted-7-Boryl Indoles and Compounds. U.S. Pat. Appl. Publ. 20080167476, 2008.

Smith, M. R., III.; Maleczka, R. E., Jr.; Chotana, Ghayoor A. Process for Producing Cyano Substituted Arenes Boranes and Compounds. World Patent Appl. WO/2006/135705. European Patent Appl. EP20060772611, European Pat. # EP1904441.

CONFERENCE ORAL PRESENTATIONS/POSTERS:

Ghaffari, B.; Vanchura, B. A., II; Chotana, Ghayoor A.; Maleczka, R. E., Jr.; Smith, M. R., III “Tuning five-coordinate trisboryl iridium catalyst reactivity through ligand modification” R. 251st American Chemical Society National Meeting, March 13–17, San Diego, CA; The Division of Inorganic Chemistry of the American Chemical Society: Washington, DC, 2016; INOR 353.

Ghaffari, B.; Vanchura, B. A., II; Chotana, Ghayoor A.; Staples, R. J.; Holmes, D.; Maleczka, R. E., Jr.; Smith, M. R., III “Reversible Borylene Formation from Ring Opening of Pinacolborane and Other Intermediates Generated from Five-Coordinate Tris-Boryl Complexes: Implications for Catalytic C–H Borylation" 8th Annual Negishi-Brown Symposium, Purdue University, West Lafayette, IN; July 12–14, 2015.

Susanne L. Miller; Chotana, Ghayoor A.; Jonathan A. Fritz; Robert E. Maleczka; Smith, Milton R., III; Selective Borylation of sp2 C-H Bonds that are Ortho or Meta to Steriaclly Diminutive Substitutents. 44th ACS Central Regional Meeting, May 15–17, Central Michigan University, Mount Pleasant, MI, 2013.

Smith, Milton R.; Chotana, Ghayoor A.; Jonathan A. Fritz; Susanne L. Miller; Robert E. Maleczka; Ligand Effects in C-H Borylation. Abstracts of Papers, 245th ACS National Meeting, New Orleans, LA, United States, April 7-11, 2013.

Chotana, Ghayoor A.; Transition Metal Catalyzed Cross-Coupling Reactions, Lahore College for Women University, Lahore Pakistan, May 18, 2011.

Chotana, Ghayoor A.; Iridium Catalyzed Aromatic C-H Activation/Borylation. First Chemistry Alumni Meeting and Seminar on “Frontiers of Chemistry” Department of Chemistry, Quaid-i-Azam University, Islamabad Pakistan, May 15-16, 2009.

Vanchura, B. A.; Ramanathan, B-S.; Chotana, Ghayoor A.; Smith, Milton R., III. Iridium Catalyzed Aromatic Borylation: What’s up with the Metal? Abstracts of Papers, 237th ACS National Meeting, Salt Lake City, UT, United States, March 22-26, 2009.

Chotana, Ghayoor A.; Mindiola, D. J. New Organometallic Chemistry of V and Ti with Dibenzotetramethyltetraaza [14] Annulene based Ligands. Purdue Indiana Notre Dame Universities (PINDU) Inorganic Symposium, Bloomington, IN, United States, November 2008.

Maleczka, R. E., Jr.; Cho, J-Y.; Chotana, Ghayoor A.; Holmes, D.; Iverson, C. N.; Kallepalli, Venkata A.; Norberg, M.; Onyeozili, E. N.; Paul, S; Sanchez, L.; Shi, F.; Tse, M-K.; Smith, Milton R., III. Green Chemistry for Preparing Boronic Esters. Presidential Green Chemistry Challenge Award Section of the 12th Annual Green Chemistry and Engineering Conference, Washington, DC, United States, June 24-26, 2008.

Kallepalli, V. A.; Chotana, Ghayoor A.; Sulagna, P.; Maleczka, R. E., Jr.; Smith, Milton R., III. Elaborating Thiophenes, Pyrroles, and Indoles. Boron in the America XI, Saint Louis, MO, United States, June 4-8, 2008.

Maleczka, R. E., Jr.; Chotana, Ghayoor A.; Kallepalli, V. A.; Holmes, D.; Norberg, M.; Sanchez, L.; Shi, F.; Smith, Milton R., III. Catalytic Borylation/Cross-Coupling Protocols that avoid the Preparation of Haloaromatics. Abstracts, 40th Middle Atlantic Regional Meeting of the American Chemical Society, Queens, NY, United States, May 17-21, 2008.

Chotana, Ghayoor A.; Vanchura, B. A.; Smith, Milton R., III. Syntheses of Five-coordinate Intermediates in Ir-catalyzed Borylations. Abstracts of Papers, 234rd ACS National Meeting, Boston, MA, United States, August 19-23, 2007.

Chotana, Ghayoor A.; Maleczka, R. E., Jr.; Smith, Milton R., III. Syntheses and Catalytic Activity of Tris-Boryl Iridium Complexes. Abstracts of Papers, 233rd ACS National Meeting, Chicago, IL, United States, March 25-29, 2007.

Chotana, Ghayoor A.; Paul, Sulagna; Kallepalli, Venkata A.; Maleczka, R. E., Jr.; Smith, Milton R., III. Ir-catalyzed Borylation: Functionalization of C-H bonds in Heterocycles. Abstracts of Papers, 232nd ACS National Meeting, San Francisco, CA, United States, Sept. 10-14, 2006.

Chotana, Ghayoor A.; Sulagna, P.; Kallepalli, V. A.; Banerjee A.; Maleczka, R. E., Jr.; Smith, Milton R., III. Ir-Catalyzed Borylation: Novel, Regioselective Functionalizations of Aromatic and Heteroaromatic Substrates. Boron in the America X, San Juan, PR, United States, August 2-7, 2006.

Chotana, Ghayoor A.; Holmes, D.; Maleczka, R. E., Jr.; Smith, M. R., III. Tandem Aromatic C-H Activation/Borylation C X coupling. Abstracts of Papers, 230th ACS National Meeting, Washington, DC, United States, Aug. 28 Sept.1, 2005.

Paul, S; Holmes, D.; Chotana, Ghayoor A.; Smith, Milton R., III. Regioselective C-H Activation of Indoles. Abstracts of Papers, 230th ACS National Meeting, Washington, DC, United States, Aug. 28-Sept. 1, 2005.

Kallepalli, V. A.; Chotana, Ghayoor A.; Maleczka, R. E., Jr.; Smith, M. R., III. Regioselective Borylation of Pyrroles and Azaindoles. Abstracts of Papers, 230th ACS National Meeting, Washington, DC, United States, Aug. 28-Sept.1, 2005.

Chotana, Ghayoor A.; Rak, M. A.; Smith, M. R., III. Sterically Directed Functionalization of Aromatic C-H bonds: Selective Borylation ortho to Cyano Groups in Arenes and Heterocycles. 39th National Organic Chemistry Symposium, University of Utah, June 12-16, 2005.

Shi, F.; Holmes, D.; Chotana, Ghayoor A.; Gong, Y.; Smith, M. R., III; Maleczka, R. E., Jr. C-H Activation/ Borylation-based One-pot Preparations of Substituted Aromatic Building Blocks for Organic Synthesis. Abstracts, 36th Central Regional Meeting of the American Chemical Society, Indianapolis, IN, United States, June 2-4, 2004.

Catalysis and Green Chemistry