Department of Biology presents
Hypoadiponectinemia Instigates NLRP3 Inflammasome Activation Mediates Alzheimer Disease and Associated Dementia
A Talk by by Dr. Shahid Ali Shah
Date: Wednesday, October 24, 2018
Time: 11:00 am – 12:00 pm
Venue: Dean’s Smart Lab, 4th floor, SBASSE Building
Host: Dr. Amir Faisal
Abstract
The link between hypoadiponectinemia induced energy deprivation and NLRP3 inflammasome activation in the brain remains elusive. Here, the Speaker reports for the first time that NLRP3 inflammasome activation in young adiponectin knockout (AKO), aged AKO and APP/PS1 mice brain. Activated NLRP3 inflammasome triggered amyloidogenic amyloid beta (Aβ) production and aggregation, caused memory impairments and suppressed long term potentiation (LTP) and associated dementia.
About the Speaker
Dr. Shah is a young Neurobiologist, working as an Assistant Professor at Islamia College University, Peshawar Pakistan. He got his PhD degree in Neurobiology from Gyeongsang National University, South Korea. Dr. Shah was also a Postdoctoral Scientist for two years and published more than 20 SCI research articles with 100 plus impact factor. The highest impact factor first author paper is in “Molecular Psychiatry” (with an impact factor of 15 in Nature Publishing Group).
