Syed Babar Ali School of Science and Engineering to hold talk on, "Identification of CHRNA5 as Breast Cancer Biomarker Using Meta-analysis and Development of E2S (Estrogen (E2) to Survival) Database".
Speaker: Dr. Huma Shehwana
Date: October 4, 2017
Time: 3:30 pm – 4:30 pm
Venue: Smart Room, SBASSE 5th Floor
Host: Dr. Syeda Kahekshan Hijazi
About the Speaker
Dr. Shehwani completed her BS in bioinformatics from International Islamic University, Islamabad in 2011 and was awarded a HEC fellowship for masters leading to PhD from Bilkent University, Ankara, Turkey during September 2012 - August 2017. During her PhD, Dr. Shehwani has worked as a bioinformatician and was involved in several breast cancer oriented research projects.
Abstract
CHRNA5 is a subunit of cholinergic receptors and its role in breast cancer has not been studied before. In the present study, role of CHRNA5 in breast cancer is studied for its association with epithelial-to-mesenchymal transition (EMT), epithelial differentiation, estrogen signalling, estrogen (E2) signalling and patient survival. Meta-analysis of in-vitro and in-vivo microarray expression datasets showed that CHRNA5, itself, and its positively co-expressed gene neighbours were likely secondary targets of E2-signaling; overexpressed in ER- breast cancer patients; and indicators of worse prognosis. Functional annotation revealed that CHRNA5 and its co-expression network was indeed associated with proliferation related pathways. Based on meta-analysis of different cohorts processed in the study, an online database E2S (Estrogen (E2) to Survival) was developed that can facilitate user to query any gene for evaluation of E2-mediated effects, regulation by estrogen receptor (ER), prognostic importance and co-expression network along with functional annotations.
